Muhas University Institution Repository >
School of Medicine >
Medicine - Journals >
Please use this identifier to cite or link to this item:
|Title: ||Abacavir alters the transcription of inflammatory cytokines in virologically suppressed, HIV-infected women.|
|Authors: ||MacLeod, I.J.|
van Widenfelt, E.
|Keywords: ||Abacavir alters|
|Issue Date: ||2012|
|Series/Report no.: ||Journal of the International AIDS Society. 2012;15(2):17393.|
Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation.
To evaluate the induction of inflammatory cytokine transcription by ABC, we used samples from women randomized to receive zidovudine/lamivudine/ABC (Trizivir) or lopinavir/ritonavir and zidovudine/lamividine (Kaletra/Combivir) from the third trimester through six-months postpartum for the prevention of mother-to-child transmission (PMTCT). Women were matched by CD4 count and baseline HIV RNA. All women attained viral suppression (<50 copies/ml) by the time of sampling.
Four cytokines showed a difference in expression between the treatment arms, all in a proinflammatory direction for the ABC arm: CD40LG 1.82-fold, (p=.027); IL-8 3.16-fold (p=.020); LTA 2.82-fold, (p=.008); and CCL5 -1.67-fold, (p=.035). At 12-months postpartum, 6-months after antiretroviral discontinuation, cytokine expression was similar by treatment arm.
We conclude that ABC may upregulate proinflammatory cytokines at the transcriptional level in this population.|
|Appears in Collections:||Medicine - Journals|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.